Acid chloride - Names and Identifiers
Acid chloride - Physico-chemical Properties
| Use | Application of acid chloride compounds in New Medicine plays an important role, the use of acid chloride compounds in the active group and catalytic effect, can be synthesized a series of pharmaceutical and chemical products and intermediates, and can provide some pharmaceutical derivatives of the preparation. Such as 2, 6-dichloro-5-fluoronicotinoyl chloride by β-ketone esterification of 2, 6-dichloro-5-fluoronicotinoyl ethyl acetate, it can be used as the key intermediates of fluoroquinolone drugs containing naphthyridine ring, such as enoxacin and gemifloxacin. The linoleic acid chloride synthesized from linoleic acid and vitamin E is an important intermediate for the synthesis of vitamin E linoleate, vitamin E linoleic acid ester can be used as a tumor suppressor, can also be formulated high-grade cosmetics, the skin, hair with nutrition, moisture and anti-aging effect; n-4-hydroxyphenethyl-4-chlorobenzamide, synthesized from p-chlorobenzoyl chloride and p-hydroxyphenylethylamine, is an important intermediate for the synthesis of Bezafibrate, which can be used to regulate lipid metabolism disorders, it can be used to treat Ⅱ B, Ⅲ and Ⅳ hyperlipidemia clinically. |
Acid chloride - Introduction
Acid chloride(Acid chloride) is a class of compounds with acyl (carbonyl) and chlorine atoms. Its chemical formula is usually RCOCl, where R represents an organic group.
About the nature of the Acid chloride:
1. Acid chloride presents a pungent pungent odor and is very volatile.
2. It can react with water to generate the corresponding acid and salt.
3. Acid chloride can be used as a strong acidic reagent, reacting with bases to generate salts and acyl bases.
Some common uses of Acid chloride:
1. Acid chloride can be used for acylation reactions to introduce acyl groups into other molecules. This reaction is commonly used to synthesize organic compounds such as drugs, dyes and fragrances.
2. Acid chloride can be used as intermediates for the preparation of amides, esters, ketones and ethers.
3. Acid chloride can also be used for the synthesis of polymer compounds, such as polyamide and polyester.
Preparation of Acid chloride:
The preparation of
Acid chloride typically involves the reaction of an acid and a chlorinating agent. Common preparation methods include:
1. In the presence of carbonate and acyl aluminum chloride, an acid is added to the reaction system. The resulting Acid chloride can be extracted with an extractant.
2. Use phosphorus Acid chloride(PCl3) or phosphorus chloride (PCl5) to react with acid to generate the corresponding Acid chloride.
Security information for Acid chloride:
1. Acid chloride is a strong sensitizer and corrosive agent, which is irritating to skin, eyes and respiratory tract.
2. When using Acid chloride, wear personal protective equipment such as protective gloves, goggles and gas masks.
3. Acid chloride should be stored in a sealed container, away from fire and oxidizing agents.
4. When using Acid chloride, care should be taken to avoid contact with water and humidity to avoid violent reaction with water to produce dangerous hydrogen chloride gas.
Please note that when handling and using Acid chloride, you should follow the correct safety operation methods and operate under the guidance of professionals.
Last Update：2024-04-09 21:54:55